Osteogenic Responses to Zirconia with Hydroxyapatite Coating by Aerosol Deposition
Identifieur interne : 000E73 ( Main/Exploration ); précédent : 000E72; suivant : 000E74Osteogenic Responses to Zirconia with Hydroxyapatite Coating by Aerosol Deposition
Auteurs : Y. Cho [Corée du Sud] ; J. Hong [Corée du Sud] ; H. Ryoo [Corée du Sud] ; D. Kim [Corée du Sud] ; J. Park [Corée du Sud] ; J. Han [Corée du Sud]Source :
- Journal of Dental Research [ 0022-0345 ] ; 2015.
Abstract
Previously, we found that osteogenic responses to zirconia co-doped with niobium oxide (Nb2O5) or tantalum oxide (Ta2O5) are comparable with responses to titanium, which is widely used as a dental implant material. The present study aimed to evaluate the in vitro osteogenic potential of hydroxyapatite (HA)-coated zirconia by an aerosol deposition method for improved osseointegration. Surface analysis by scanning electron microscopy and x-ray diffraction proved that a thin as-deposited HA film on zirconia showed a shallow, regular, crater-like surface. Deposition of dense and uniform HA films was measured by SEM, and the contact angle test demonstrated improved wettability of the HA-coated surface. Confocal laser scanning microscopy indicated that MC3T3-E1 pre-osteoblast attachment did not differ notably between the titanium and zirconia surfaces; however, cells on the HA-coated zirconia exhibited a lower proliferation than those on the uncoated zirconia late in the culture. Nevertheless, ALP, alizarin red S staining, and bone marker gene expression analysis indicated good osteogenic responses on HA-coated zirconia. Our results suggest that HA-coating by aerosol deposition improves the quality of surface modification and is favorable to osteogenesis.
Url:
DOI: 10.1177/0022034514566432
PubMed: 25586588
PubMed Central: 4814017
Affiliations:
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Cho</name><affiliation wicri:level="4"><nlm:aff id="aff1-0022034514566432">Department of Prosthodontics, School of Dentistry and Dental Research Institute, BK21 Program, Seoul National University, Seoul, Korea</nlm:aff><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Department of Prosthodontics, School of Dentistry and Dental Research Institute, BK21 Program, Seoul National University, Seoul</wicri:regionArea><placeName><settlement type="city">Séoul</settlement><region type="capital">Région capitale de Séoul</region><settlement type="city">Séoul</settlement></placeName><orgName type="university">Université nationale de Séoul</orgName></affiliation><affiliation wicri:level="4"><nlm:aff id="aff2-0022034514566432">Department of Periodontology, School of Dentistry and Dental Research Institute, BK21 Program, Seoul National University, Seoul, Korea</nlm:aff><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Department of Periodontology, School of Dentistry and Dental Research Institute, BK21 Program, Seoul National University, Seoul</wicri:regionArea><placeName><settlement type="city">Séoul</settlement><region type="capital">Région capitale de Séoul</region><settlement type="city">Séoul</settlement></placeName><orgName type="university">Université nationale de Séoul</orgName></affiliation><affiliation wicri:level="4"><nlm:aff id="aff3-0022034514566432">Department of Molecular Genetics, School of Dentistry and Dental Research Institute, BK21 Program, Seoul National University, Seoul, Korea</nlm:aff><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Department of Molecular Genetics, School of Dentistry and Dental Research Institute, BK21 Program, Seoul National University, Seoul</wicri:regionArea><placeName><settlement type="city">Séoul</settlement><region type="capital">Région capitale de Séoul</region><settlement type="city">Séoul</settlement></placeName><orgName type="university">Université nationale de Séoul</orgName></affiliation></author><author><name sortKey="Hong, J" sort="Hong, J" uniqKey="Hong J" first="J." last="Hong">J. 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Han</name><affiliation wicri:level="4"><nlm:aff id="aff1-0022034514566432">Department of Prosthodontics, School of Dentistry and Dental Research Institute, BK21 Program, Seoul National University, Seoul, Korea</nlm:aff><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Department of Prosthodontics, School of Dentistry and Dental Research Institute, BK21 Program, Seoul National University, Seoul</wicri:regionArea><placeName><settlement type="city">Séoul</settlement><region type="capital">Région capitale de Séoul</region><settlement type="city">Séoul</settlement></placeName><orgName type="university">Université nationale de Séoul</orgName></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">25586588</idno><idno type="pmc">4814017</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4814017</idno><idno type="RBID">PMC:4814017</idno><idno type="doi">10.1177/0022034514566432</idno><date when="2015">2015</date><idno type="wicri:Area/Pmc/Corpus">000597</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000597</idno><idno type="wicri:Area/Pmc/Curation">000597</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000597</idno><idno type="wicri:Area/Pmc/Checkpoint">000B99</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000B99</idno><idno type="wicri:Area/Ncbi/Merge">005778</idno><idno type="wicri:Area/Ncbi/Curation">005778</idno><idno type="wicri:Area/Ncbi/Checkpoint">005778</idno><idno type="wicri:doubleKey">0022-0345:2015:Cho Y:osteogenic:responses:to</idno><idno type="wicri:Area/Main/Merge">000E75</idno><idno type="wicri:Area/Main/Curation">000E73</idno><idno type="wicri:Area/Main/Exploration">000E73</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Osteogenic Responses to Zirconia with Hydroxyapatite Coating by Aerosol Deposition</title><author><name sortKey="Cho, Y" sort="Cho, Y" uniqKey="Cho Y" first="Y." last="Cho">Y. Cho</name><affiliation wicri:level="4"><nlm:aff id="aff1-0022034514566432">Department of Prosthodontics, School of Dentistry and Dental Research Institute, BK21 Program, Seoul National University, Seoul, Korea</nlm:aff><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Department of Prosthodontics, School of Dentistry and Dental Research Institute, BK21 Program, Seoul National University, Seoul</wicri:regionArea><placeName><settlement type="city">Séoul</settlement><region type="capital">Région capitale de Séoul</region><settlement type="city">Séoul</settlement></placeName><orgName type="university">Université nationale de Séoul</orgName></affiliation><affiliation wicri:level="4"><nlm:aff id="aff2-0022034514566432">Department of Periodontology, School of Dentistry and Dental Research Institute, BK21 Program, Seoul National University, Seoul, Korea</nlm:aff><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Department of Periodontology, School of Dentistry and Dental Research Institute, BK21 Program, Seoul National University, Seoul</wicri:regionArea><placeName><settlement type="city">Séoul</settlement><region type="capital">Région capitale de Séoul</region><settlement type="city">Séoul</settlement></placeName><orgName type="university">Université nationale de Séoul</orgName></affiliation><affiliation wicri:level="4"><nlm:aff id="aff3-0022034514566432">Department of Molecular Genetics, School of Dentistry and Dental Research Institute, BK21 Program, Seoul National University, Seoul, Korea</nlm:aff><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Department of Molecular Genetics, School of Dentistry and Dental Research Institute, BK21 Program, Seoul National University, Seoul</wicri:regionArea><placeName><settlement type="city">Séoul</settlement><region type="capital">Région capitale de Séoul</region><settlement type="city">Séoul</settlement></placeName><orgName type="university">Université nationale de Séoul</orgName></affiliation></author><author><name sortKey="Hong, J" sort="Hong, J" uniqKey="Hong J" first="J." last="Hong">J. Hong</name><affiliation wicri:level="4"><nlm:aff id="aff1-0022034514566432">Department of Prosthodontics, School of Dentistry and Dental Research Institute, BK21 Program, Seoul National University, Seoul, Korea</nlm:aff><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Department of Prosthodontics, School of Dentistry and Dental Research Institute, BK21 Program, Seoul National University, Seoul</wicri:regionArea><placeName><settlement type="city">Séoul</settlement><region type="capital">Région capitale de Séoul</region><settlement type="city">Séoul</settlement></placeName><orgName type="university">Université nationale de Séoul</orgName></affiliation></author><author><name sortKey="Ryoo, H" sort="Ryoo, H" uniqKey="Ryoo H" first="H." last="Ryoo">H. Ryoo</name><affiliation wicri:level="4"><nlm:aff id="aff3-0022034514566432">Department of Molecular Genetics, School of Dentistry and Dental Research Institute, BK21 Program, Seoul National University, Seoul, Korea</nlm:aff><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Department of Molecular Genetics, School of Dentistry and Dental Research Institute, BK21 Program, Seoul National University, Seoul</wicri:regionArea><placeName><settlement type="city">Séoul</settlement><region type="capital">Région capitale de Séoul</region><settlement type="city">Séoul</settlement></placeName><orgName type="university">Université nationale de Séoul</orgName></affiliation></author><author><name sortKey="Kim, D" sort="Kim, D" uniqKey="Kim D" first="D." last="Kim">D. Kim</name><affiliation wicri:level="3"><nlm:aff id="aff4-0022034514566432">Department of Advanced Materials Engineering, Sejong University, Seoul, Korea</nlm:aff><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Department of Advanced Materials Engineering, Sejong University, Seoul</wicri:regionArea><placeName><settlement type="city">Séoul</settlement><region type="capital">Région capitale de Séoul</region></placeName></affiliation></author><author><name sortKey="Park, J" sort="Park, J" uniqKey="Park J" first="J." last="Park">J. Park</name><affiliation wicri:level="1"><nlm:aff id="aff5-0022034514566432">R&D Center, Nano Business, IONES Co., Ltd., Gyeonggi-do, Korea</nlm:aff><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>R&D Center, Nano Business, IONES Co., Ltd., Gyeonggi-do</wicri:regionArea><wicri:noRegion>Gyeonggi-do</wicri:noRegion></affiliation></author><author><name sortKey="Han, J" sort="Han, J" uniqKey="Han J" first="J." last="Han">J. Han</name><affiliation wicri:level="4"><nlm:aff id="aff1-0022034514566432">Department of Prosthodontics, School of Dentistry and Dental Research Institute, BK21 Program, Seoul National University, Seoul, Korea</nlm:aff><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Department of Prosthodontics, School of Dentistry and Dental Research Institute, BK21 Program, Seoul National University, Seoul</wicri:regionArea><placeName><settlement type="city">Séoul</settlement><region type="capital">Région capitale de Séoul</region><settlement type="city">Séoul</settlement></placeName><orgName type="university">Université nationale de Séoul</orgName></affiliation></author></analytic><series><title level="j">Journal of Dental Research</title><idno type="ISSN">0022-0345</idno><idno type="eISSN">1544-0591</idno><imprint><date when="2015">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Previously, we found that osteogenic responses to zirconia co-doped with niobium oxide (Nb<sub>2</sub>O<sub>5</sub>) or tantalum oxide (Ta<sub>2</sub>O<sub>5</sub>) are comparable with responses to titanium, which is widely used as a dental implant material. The present study aimed to evaluate the in vitro osteogenic potential of hydroxyapatite (HA)-coated zirconia by an aerosol deposition method for improved osseointegration. Surface analysis by scanning electron microscopy and x-ray diffraction proved that a thin as-deposited HA film on zirconia showed a shallow, regular, crater-like surface. Deposition of dense and uniform HA films was measured by SEM, and the contact angle test demonstrated improved wettability of the HA-coated surface. Confocal laser scanning microscopy indicated that MC3T3-E1 pre-osteoblast attachment did not differ notably between the titanium and zirconia surfaces; however, cells on the HA-coated zirconia exhibited a lower proliferation than those on the uncoated zirconia late in the culture. Nevertheless, ALP, alizarin red S staining, and bone marker gene expression analysis indicated good osteogenic responses on HA-coated zirconia. Our results suggest that HA-coating by aerosol deposition improves the quality of surface modification and is favorable to osteogenesis.</p></div></front></TEI><affiliations><list><country><li>Corée du Sud</li></country><region><li>Région capitale de Séoul</li></region><settlement><li>Séoul</li></settlement><orgName><li>Université nationale de Séoul</li></orgName></list><tree><country name="Corée du Sud"><region name="Région capitale de Séoul"><name sortKey="Cho, Y" sort="Cho, Y" uniqKey="Cho Y" first="Y." last="Cho">Y. Cho</name></region><name sortKey="Cho, Y" sort="Cho, Y" uniqKey="Cho Y" first="Y." last="Cho">Y. Cho</name><name sortKey="Cho, Y" sort="Cho, Y" uniqKey="Cho Y" first="Y." last="Cho">Y. Cho</name><name sortKey="Han, J" sort="Han, J" uniqKey="Han J" first="J." last="Han">J. Han</name><name sortKey="Hong, J" sort="Hong, J" uniqKey="Hong J" first="J." last="Hong">J. Hong</name><name sortKey="Kim, D" sort="Kim, D" uniqKey="Kim D" first="D." last="Kim">D. Kim</name><name sortKey="Park, J" sort="Park, J" uniqKey="Park J" first="J." last="Park">J. Park</name><name sortKey="Ryoo, H" sort="Ryoo, H" uniqKey="Ryoo H" first="H." last="Ryoo">H. Ryoo</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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